Prof Julien Gautrot
Professor in Biomaterials and Biointerfaces
Centre Lead
School of Engineering and Materials Science
Queen Mary University of London
+44 (0)20 7882 5263Queen Mary University of London
j.gautrot@qmul.ac.uk
www.sems.qmul.ac.uk/j.gautrot
Research
Interests
Brings expertise in the field of soft matter physico-chemistry, biointerface design and stem cell technologies.Publications
2024
Murphy JF, Lavelle M, Asciak L, Burdis R, Levis HJ, Ligorio C, McGuire J, Polleres M, Smith PO, Tullie L, Uribe-Gomez J, Chen B, Dawson JI, Gautrot JE, Hooper NM, Kelly DJ, Li VSW, Mata A, Pandit A, Phillips JB, Shu W, Stevens MM, Williams RL, Armstrong JPK and Huang YYS (2024). Biofabrication and biomanufacturing in Ireland and the UK. Springer Nature Bio-Design and Manufacturing 1-32. 10.1007/s42242-024-00316-z
Zhang J, Marciano D, Wang L, Wang W, Gossen M, Yang M, Peng T, Gautrot J, Xu X and Ma N (2024). Bioinspired Hyaluronic Acid‐Based Hydrogel Fuels Bi‐Directional Lung Organoid Maturation via PIEZO1 and ITGB1 Mediated Mechanosensation. Wiley Advanced Materials Interfaces 10.1002/admi.202400194
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill FR (2024). Human 3D Ovarian Cancer Models Reveal Malignant Cell-Intrinsic and -Extrinsic Factors That Influence CAR T-cell Activity. Cancer Res vol. 84, (15) 2432-2449. 10.1158/0008-5472.CAN-23-3007
Marchena MH, Lambert E, Bogdanović B, Quadir F, Neri-Cruz CE, Luo J, Nadal C, Migliorini E and Gautrot JE (2024). BMP-Binding Polysulfonate Brushes to Control Growth Factor Presentation and Regulate Matrix Remodelling. American Chemical Society (Acs) Acs Applied Materials & Interfaces vol. 16, (31) 40455-40468. 10.1021/acsami.4c05139
Mojares E, Nadal C, Hayler D, Kanso H, Chrysanthou A, Cruz CEN and Gautrot JE (2024). Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on Microdroplets. Wiley Advanced Materials vol. 36, (38) 10.1002/adma.202406333
Chrysanthou A, Bosch-Fortea M, Nadal C, Zarbakhsh A and Gautrot JE (2024). Interfacial mechanics of β-casein and albumin mixed protein assemblies at liquid-liquid interfaces. Elsevier Journal of Colloid and Interface Science vol. 674, 379-391. 10.1016/j.jcis.2024.06.111
Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M and O’Toole E (2024). O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics. Oxford University Press (Oup) British Journal of Dermatology vol. 190, (6) e71-e72. 10.1093/bjd/ljae105.008
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I, Annibaldi A, Gautrot J and Balkwill FR (2024). Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity. American Association For Cancer Research (Aacr) Cancer Research vol. 84, (5_Supplement_2) b079-b079. 10.1158/1538-7445.ovarian23-b079
Di Cio S, Marhuenda E, Haddrick M and Gautrot JE (2024). Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Springer Nature Scientific Reports vol. 14, (1) 10.1038/s41598-024-53678-w
Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2024). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. F1000research F1000research vol. 12, 10.12688/f1000research.131810.2
2023
Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E (2023). P16 How does skin ageing-related basement membrane collagen loss affect the nucleus? Oxford University Press (Oup) British Journal of Dermatology vol. 189, (1) e20-e20. 10.1093/bjd/ljad174.037
Neri-Cruz CE, Teixeira FME and Gautrot JE (2023). A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes. Royal Society of Chemistry Chemical Communications vol. 59, (49) 7534-7558. 10.1039/d3cc01082a
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E (2023). 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus. Elsevier Journal of Investigative Dermatology vol. 143, (5) s127-s127. 10.1016/j.jid.2023.03.750
Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2023). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. Taylor and Francis F1000research vol. 12, 439-439. 10.12688/f1000research.131810.1
Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M (2023). Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization. Mdpi Molecules vol. 28, (9) 10.3390/molecules28093686
Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Springer Nature Scientific Reports vol. 13, (1) 10.1038/s41598-023-31352-x
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 4576-4576. 10.1158/1538-7445.am2023-4576
Peng L, Nadal C and Gautrot JE (2023). Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils. Iop Publishing Biomedical Materials vol. 18, (3) 10.1088/1748-605x/acbdda
Peng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE (2023). Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces. Wiley Advanced Healthcare Materials vol. 12, (13) 10.1002/adhm.202203297
Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE (2023). Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene Coupling. American Chemical Society (Acs) Acs Applied Polymer Materials vol. 5, (2) 1364-1373. 10.1021/acsapm.2c01878
Chrysanthou A, Bosch-Fortea M and Gautrot JE (2023). Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion. American Chemical Society (Acs) Biomacromolecules vol. 24, (10) 4465-4477. 10.1021/acs.biomac.2c01289
Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE (2023). Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions. American Chemical Society (Acs) Acs Applied Materials & Interfaces vol. 15, (2) 2760-2770. 10.1021/acsami.2c20188
Kaur A, Gautrot JE, Akutagawa K, Watson D, Bickley A and Busfield JJC (2023). Thiyl radical induced cis / trans isomerism in double bond containing elastomers. Royal Society of Chemistry (Rsc) Rsc Advances vol. 13, (34) 23967-23975. 10.1039/d3ra04157c
2022
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2022). Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubber. Constitutive Models For Rubber Xii Taylor & Francis 10.1201/9781003310266-38
Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A (2022). The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study. Wiley Advanced Materials Interfaces 10.1002/admi.202201344
Jones CFE, Di Cio S, Connelly JT and Gautrot JE (2022). Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model. Frontiers Media Frontiers in Bioengineering and Biotechnology vol. 10, 10.3389/fbioe.2022.915702
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. Mdpi Biomolecules vol. 12, (6) 10.3390/biom12060837
Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS (2022). Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions. Wiley Small Methods vol. 6, (6) 10.1002/smtd.202200152
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE (2022). Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces. Elsevier Biomaterials vol. 284, 10.1016/j.biomaterials.2022.121494
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR (2022). Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin. American Chemical Society (Acs) Biomacromolecules vol. 23, (3) 1423-1432. 10.1021/acs.biomac.1c01660
2021
Peng L and Gautrot JE (2021). Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers. Elsevier Materials Today Bio vol. 12, 100159-100159. 10.1016/j.mtbio.2021.100159
Raynold AAM, Li D, Chang L and Gautrot JE (2021). Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors. Springer Nature Nature Communications vol. 12, (1) 10.1038/s41467-021-26695-w
Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE (2021). Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air. American Chemical Society Acs Applied Polymer Materials 10.1021/acsapm.1c00440
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2021). Novel Crosslinking System for Poly-Chloroprene Rubber to Enable Recyclability and Introduce Self-Healing. Mdpi Polymers vol. 13, (19) 10.3390/polym13193347
Megone W, Tang P, Roohpour N and Gautrot JE (2021). Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels. Arkat Usa Arkivoc vol. 2021, (6) 101-119. 10.24820/ark.5550190.p011.516
Chang L, Yan H, Chang J and Gautrot JE (2021). Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors. Elsevier European Polymer Journal 110593-110593. 10.1016/j.eurpolymj.2021.110593
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society Acs Applied Materials and Interfaces vol. 13, (22) 25792-25804. 10.1021/acsami.1c05574
Megone W, Kong D, Peng L and Gautrot JE (2021). Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets. Elsevier Journal of Colloid and Interface Science vol. 594, 650-657. 10.1016/j.jcis.2021.03.055
Qu F, Ma X and Gautrot JE (2021). Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis. Elsevier Biosensors and Bioelectronics vol. 179, 113045-113045. 10.1016/j.bios.2021.113045
Cozens EJ, Roohpour N and Gautrot JE (2021). Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues. Elsevier European Polymer Journal 110250-110250. 10.1016/j.eurpolymj.2020.110250
Qu F, Raynold AM and Gautrot JE (2021). Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications. Soft Matter For Biomedical Applications Royal Society of Chemistry (Rsc) 10.1039/9781839161124-00264
2020
Zhang X, Shi X, Gautrot JE and Peijs T (2020). Nanoengineered electrospun fibers and their biomedical applications: a review. Taylor & Francis Nanocomposites vol. 7, (1) 1-34. 10.1080/20550324.2020.1857121
Suzuki K and Gautrot J (2020). Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac Repair. Elsevier Biomaterials 10.1016/j.biomaterials.2020.120356
You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. Elsevier Biomaterials 120356-120356. 10.1016/j.biomaterials.2020.120356
Li D, Xu L, Wang J and Gautrot JE (2020). Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics. Wiley Advanced Healthcare Materials 10.1002/adhm.202000953
Wu L, Di Cio S, Azevedo HS and Gautrot JE (2020). Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels. American Chemical Society Biomacromolecules 10.1021/acs.biomac.0c00603
Colak B, Wu L, Cozens EJ and Gautrot JE (2020). Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell Encapsulation. American Chemical Society Acs Applied Bio Materials 10.1021/acsabm.0c00908
Zhang X, Megone W, Peijs T and Gautrot JE (2020). Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites. Taylor & Francis Group Nanocomposites 10.1080/20550324.2020.1784600
2019
Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Elsevier Biomaterials vol. 232, 10.1016/j.biomaterials.2019.119683
Cozens EJ, Kong D, Roohpour N and Gautrot JE (2019). The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues. Royal Society of Chemistry Soft Matter vol. 16, (2) 505-522. 10.1039/c9sm01403a
Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J (2019). Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery. Royal Society of Chemistry Chemical Communications vol. 55, (94) 14166-14169. 10.1039/c9cc05790k
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules vol. 20, (7) 2506-2514. 10.1021/acs.biomac.9b00245
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). Photo‐Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019). Wiley Advanced Functional Materials vol. 29, (24) 10.1002/adfm.201970165
Qu F, Li D, Ma X, Chen F and Gautrot JE (2019). A Kinetic Model of Oligonucleotide–Brush Interactions for the Rational Design of Gene Delivery Vectors. American Chemical Society (Acs) Biomacromolecules vol. 20, (6) 2218-2229. 10.1021/acs.biomac.9b00155
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites. Wiley Advanced Functional Materials vol. 29, (24) 10.1002/adfm.201900738
Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. Mdpi Sensors vol. 19, (7) 10.3390/s19071677
GAUTROT JEE (2019). Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETAC. American Chemical Society Langmuir 10.1021/acs.langmuir.8b04268
GAUTROT JEE (2019). Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatite. Elsevier Journal of Colloid and Interface Science vol. 543, 237-237. 10.1016/j.jcis.2019.02.063
2018
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. Mdpi 10.3390/proceedings2130961
Kong D, Peng L, Di Cio S, Novak P and Gautrot JE (2018). Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled Nanosheets. Acs Nano vol. 12, (9) 9206-9213. 10.1021/acsnano.8b03865
Zhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE (2018). A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. Taylor & Francis International Journal of Nanomedicine vol. 13, 5701-5718. 10.2147/ijn.s163219
Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir vol. 34, (34) 10019-10027. 10.1021/acs.langmuir.8b01682
Zhang F, An Y, Roohpour N, Barber AH and Gautrot JE (2018). Hydration dependent mechanical performance of denture adhesive hydrogels. Elsevier Dental Materials vol. 34, (10) 1440-1448. 10.1016/j.dental.2018.06.015
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Elsevier Developmental Cell vol. 45, (5) 10.1016/j.devcel.2018.05.016
Megone W, Roohpour N and Gautrot JE (2018). Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials. Sci Rep vol. 8, (1) 6780-6780. 10.1038/s41598-018-24671-x
Mata A, Azevedo HS, Connelly J and Gautrot J (2018). Bioengineering Complexity and Tuneability in Hydrogels. Hydrogels Taylor & Francis 10.1201/9781315152226-17
Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE (2018). Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids. Nano Lett 10.1021/acs.nanolett.7b05339
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44, (3) 326-336.e3. 10.1016/j.devcel.2017.12.024
Li D, Sharili AS, Connelly J and Gautrot JE (2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules 10.1021/acs.biomac.7b01686
Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ (2018). Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives. Wiley Journal of Biomedical Materials Research Part A vol. 106, (5) 1355-1362. 10.1002/jbm.a.36341
Colak B, Di Cio S and Gautrot JE (2018). Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays. Biomacromolecules 10.1021/acs.biomac.7b01436
2017
Li D and Gautrot JE (2017). Design of Polymer Brushes for Cell Culture and Cellular Delivery. Polymer and Biopolymer Brushes Wiley 10.1002/9781119455042.ch20
Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE (2017). The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency. Biomacromolecules 10.1021/acs.biomac.7b01175
Darshan GH, Kong D, Gautrot J and Vootla S (2017). Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. Springer Nature Scientific Reports vol. 7, (1) 10.1038/s41598-017-10531-7
Zhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE (2017). Tunable and processable shape memory composites based on degradable polymers. Polymer 10.1016/j.polymer.2017.06.066
Kong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE (2017). The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interface. Faraday Discuss. vol. 204, 367-381. 10.1039/C7FD00091J
Di Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE (2017). Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomaterialia vol. 50, 280-292. 10.1016/j.actbio.2016.11.069
Gh D, Kong D, Gautrot J and Vootla SK (2017). Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications. Macromol Biosci vol. 17, (7) 10.1002/mabi.201600443
Amabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst K-H, Flood A, Gautrot J, Jabbarzadeh A, Korolkov V, Kühnle A, Lackinger M, Pradier C-M, Rahman T, Raval R, Schwaminger S, Seibel J, Tait SL and Teyssandier J (2017). Preparing macromolecular systems on surfaces: general discussion. Royal Society of Chemistry (Rsc) Faraday Discussions vol. 204, 395-418. 10.1039/c7fd90076g
2016
Gautrot JE (2016). Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales. Mechanobiology Wiley 10.1002/9781118966174.ch19
Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A (2016). Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Sci Rep vol. 6, 34334-34334. 10.1038/srep34334
Colak B, Da Silva JCS, Soares TA and Gautrot JE (2016). Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation. American Chemical Society Bioconjugate Chemistry vol. 27, (9) 2111-2123. 10.1021/acs.bioconjchem.6b00349
Nguyen KDQ, Megone WV, Kong D and Gautrot JE (2016). Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applications. Polymer Chemistry vol. 7, (33) 5281-5293. 10.1039/c6py01134a
Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T (2016). “Polymer-polymer composites for the design of strong and tough degradable biomaterials”. Materials Today Communications vol. 8, 53-63. 10.1016/j.mtcomm.2016.05.001
An Y, Li D, Roohpour N, Gautrot JE and Barber AH (2016). Failure mechanisms in denture adhesives. Elsevier Dental Materials vol. 32, (5) 615-623. 10.1016/j.dental.2016.01.007
Di Cio S and Gautrot JE (2016). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia vol. 30, 26-48. 10.1016/j.actbio.2015.11.027
Tan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE (2016). Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption. Royal Society of Chemistry (Rsc) Polymer Chemistry vol. 7, (4) 979-990. 10.1039/c5py01687h
2015
Di Cio S and Gautrot JE (2015). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Elsevier Acta Biomaterialia vol. 30, 26-48. 10.1016/j.actbio.2015.11.027
Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L (2015). The RAPIDOS project-European and Chinese collaborative research on biomaterials. J Orthop Translat vol. 3, (2) 78-84. 10.1016/j.jot.2015.02.001
Hackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J (2015). Conductive surfaces with dynamic switching in response to temperature and salt. Royal Society of Chemistry (Rsc) Journal of Materials Chemistry B vol. 3, (48) 9285-9294. 10.1039/c5tb02125a
2014
Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier Sensors and Actuators B: Chemical vol. 209, 230-236. 10.1016/j.snb.2014.11.071
Krishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE (2014). Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. American Chemical Society Chemical Reviews vol. 114, (21) 10976-11026. 10.1021/cr500252u
Gautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS (2014). The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction. Nano Letters vol. 14, (7) 3945-3952. 10.1021/nl501248y
Costa P, Gautrot JE and Connelly JT (2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater vol. 10, (6) 2415-2422. 10.1016/j.actbio.2014.01.029
Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated Microcapsules for Exclusive Binding to Protein Substrates. American Chemical Society (Acs) Biomacromolecules vol. 15, (7) 2555-2562. 10.1021/bm500412d
2013
Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE (2013). Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integr Biol (Camb) vol. 5, (6) 899-910. 10.1039/c3ib40026c
GAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M (2013). The surface charge of anti-bacterial coatings alters motility and biofilm architecture. Journal of Biomaterials Science: Polymer Edition vol. 1, (6) 589-602. 10.1039/C3BM00197K
2012
Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM (2012). Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials vol. 33, (21) 5221-5229. 10.1016/j.biomaterials.2012.04.009
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials 10.1038/nmat3339
2011
Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS (2011). Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun vol. 32, (13) 952-957. 10.1002/marc.201100189
Tan KY, Gautrot JE and Huck WTS (2011). Formation of pickering emulsions using ion-specific responsive colloids. Langmuir vol. 27, (4) 1251-1259. 10.1021/la102904r
Connelly JT, Mishra A, Gautrot JE and Watt FM (2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. Plos One vol. 6, (11) 10.1371/journal.pone.0027259
Tan KY, Gautrot JE and Huck WTS (2011). Island brushes to control adhesion of water in oil droplets on planar surfaces. Soft Matter vol. 7, (15) 7013-7020. 10.1039/c0sm01501f
Strandman S, Gautrot JE and Zhu XX (2011). Recent advances in entropy-driven ring-opening polymerizations. Polymer Chemistry vol. 2, (4) 791-799. 10.1039/c0py00328j
2010
Connelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology vol. 12, (7) 711-718. 10.1038/ncb2074
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS (2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials vol. 31, (18) 5030-5041. 10.1016/j.biomaterials.2010.02.066
Gautrot JE, Huck WTS, Welch M and Ramstedt M (2010). Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins. Acs Appl Mater Interfaces vol. 2, (1) 193-202. 10.1021/am9006484
Therien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX (2010). Shape memory properties of main chain bile acids polymers. Polymer vol. 51, (1) 22-25. 10.1016/j.polymer.2009.11.027
2009
Gautrot JE and Zhu XX (2009). Shape memory polymers based on naturally-occurring bile acids. Macromolecules vol. 42, (19) 7324-7331. 10.1021/ma901090r
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE (2009). Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules vol. 10, (10) 2885-2894. 10.1021/bm900706r
Gautrot JE and Zhu XX (2009). Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocks. Journal of Materials Chemistry vol. 19, (32) 5705-5716. 10.1039/b821340b
Huck WTS, Gautrot J and Watt F (2009). The effects of surface chemistry on epidermal stem cell differentiation. Abstracts of Papers of The American Chemical Society vol. 237,
Hodge P and Gautrot JE (2009). Polymers containing in-chain quinone moieties: synthesis and properties. Polymer International vol. 58, (3) 261-266. 10.1002/pi.2528
Gautrot JE, Zhang J, Shao Y and Zhu XX (2009). New degradable polymers made from natural compounds bile acids by ROMP. Abstracts of Papers of The American Chemical Society vol. 237,
Gautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D (2009). Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units. Journal of Materials Chemistry vol. 19, (24) 4148-4156. 10.1039/b901853k
2008
Gautrot JE and Zhu XX (2008). High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation. Chem Commun (Camb) (14) 1674-1676. 10.1039/b719021b
2007
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuits. 2007 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2007, Technical Proceedings vol. 2, 68-71.
Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S (2007). Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair. Macromol Biosci vol. 7, (5) 746-752. 10.1002/mabi.200700008
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir vol. 23, (3) 1047-1051. 10.1021/la0624945
Gautrot JE and Zhu XX (2007). Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study. Anal Chim Acta vol. 581, (2) 281-286. 10.1016/j.aca.2006.08.020
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2007). 2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymers. New Journal of Chemistry vol. 31, (9) 1585-1593. 10.1039/b701257h
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir vol. 23, (3) 1047-1051. 10.1021/la0624945
Chen Y, Gautrot JE, Li Z and Zhu XX (2007). Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arrays. Soft Matter vol. 3, (5) 571-579. 10.1039/b611445h
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronics. Journal of Materials Chemistry vol. 17, (17) 1725-1730. 10.1039/b616446c
Gautrot JE and Hodge P (2007). Poly(dibenzo[a,c]phenazine-2,7-diyl)s -: Synthesis and characterisation of a new family of electron-accepting conjugated polymers. Polymer vol. 48, (24) 7065-7077. 10.1016/j.polymer.2007.09.045
2006
Gautrot JE and Zhu XX (2006). Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization. Angew Chem Int Ed Engl vol. 45, (41) 6872-6874. 10.1002/anie.200602096
Gautrot JE and Zhu XX (2006). Main‐Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy‐Driven Ring‐Opening Metathesis Polymerization. Wiley Angewandte Chemie vol. 118, (41) 7026-7028. 10.1002/ange.200602096
Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX (2006). Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents. Langmuir vol. 22, (10) 4799-4803. 10.1021/la053399j
Gautrot JE and Zhu XX (2006). Biodegradable polymers based on bile acids and potential biomedical applications. Journal of Biomaterials Science-Polymer Edition vol. 17, (10) 1123-1139. 10.1163/156856206778530713
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2006). Experimental evidence for carbonyl-π electron cloud interactions. New Journal of Chemistry vol. 30, (12) 1801-1807. 10.1039/b608628d
2005
Schroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M (2005). Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistors. Applied Physics Letters vol. 87, (11) 10.1063/1.2035879
Grants
Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines (Patterned OrganChips)
Knight M, Connelly J, Dalby M, Gautrot J, Griffin X, Hopkins T and Screen H
£1,826,719 Engineering and Physical Sciences Research Council (30-06-2024 - 29-06-2027)
Knight M, Connelly J, Dalby M, Gautrot J, Griffin X, Hopkins T and Screen H
£1,826,719 Engineering and Physical Sciences Research Council (30-06-2024 - 29-06-2027)
Engineered Recombinant Strategies to Organogel Design for Food Product Formulations
Gautrot J and Lee T-Y
Biotechnology and Biological Sciences Research Council (30-09-2022 - 30-11-2026)
Gautrot J and Lee T-Y
Biotechnology and Biological Sciences Research Council (30-09-2022 - 30-11-2026)
ProNaGen: Engineering of Recombinant Protein Nanosheet-Based Bioemulsions for Next Generation Bioprocessing and Biomanufacturing
Gautrot J
£127,041 UK Research and Innovation (01-11-2023 - 29-04-2025)
Gautrot J
£127,041 UK Research and Innovation (01-11-2023 - 29-04-2025)
Unravelling mechanisms of drug-induced myocarditis using human cardiovascular-chip models integrated with immune cells
Lin Y-Y and Gautrot J
£121,420 Medical Research Council (01-10-2024 - 30-09-2024)
Lin Y-Y and Gautrot J
£121,420 Medical Research Council (01-10-2024 - 30-09-2024)
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering
GAUTROT J
EUR1,999,389 European Research Council (01-09-2018 - 31-08-2024)
GAUTROT J
EUR1,999,389 European Research Council (01-09-2018 - 31-08-2024)
Design of an organ-on-a-chip model of soft-hard tissue interfaces
Gautrot J and Da San Martino C
Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)
Gautrot J and Da San Martino C
Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)
A biophysical model of gum reintegration on enamel
Gautrot J
£109,943 Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)
Gautrot J
£109,943 Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing
GAUTROT J
EUR150,000 European Research Council (01-03-2021 - 31-08-2022)
GAUTROT J
EUR150,000 European Research Council (01-03-2021 - 31-08-2022)
Design of A Microfluidics Integrated Skin-on-a-Chip Tissue Model
Gautrot J and Jones C
Engineering and Physical Sciences Research Council (02-04-2017 - 02-10-2020)
Gautrot J and Jones C
Engineering and Physical Sciences Research Council (02-04-2017 - 02-10-2020)
To develop and exploit novel concepts and formulations for the cure chemistry of silicone composite materials and associated crosslinkers to improve the safety of silicone composites and improve their stability and cure rate.
Gautrot J
£76,494 Innovate UK (15-12-2016 - 31-08-2020)
Gautrot J
£76,494 Innovate UK (15-12-2016 - 31-08-2020)
An Ovarian Cancer Model on a Chip
Gautrot J
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (31-08-2015 - 30-08-2018)
Gautrot J
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (31-08-2015 - 30-08-2018)
Photo-responsive graphene for anti-corrosive and conductive strong, compliant silicone nanocomposites
Bilotti E and Gautrot J
£88,336 Engineering and Physical Sciences Research Council (30-09-2015 - 29-09-2016)
Bilotti E and Gautrot J
£88,336 Engineering and Physical Sciences Research Council (30-09-2015 - 29-09-2016)